Lectins

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Lectins: To Combat Infections

The term “lectin” was coined by William Boyd in 1954 from the Greek word “legere” which means “to select” or “to bind”. Lectins and hemagglutinins are proteins/glycoproteins of non-immune origin, which have at least one non-catalytic domain that exhibits reversible binding to specific monosaccharides or oligosaccharides (Lis and Sharon, 1986). The lectinmonosaccharide interactions are relativel...

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Neisseriaceae and Lectins

The lectin slide agglutination test for Neisseria gonorrhoeae has been modified and improved. Results show that wheat germ agglutinin and soybean lectin agglutinate 100% (193 of 193 tested) of clinical isolates of N. gonorrhoeae. Lectin-reactive meningococci can be readily identified by the hydrolysis of gammaglutamyl-3-naphthylamide. Branhamella catarrhalis, Neisseria lactamica, Neisseria sicc...

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Affinity Chromatography of Lectins

Affinity chromatography is a technique used to purify compounds, such as proteins, that have the ability to non-covalently and reversibly bind specific molecules, known as ligands. This method differs from the classical chromatography techniques in that the protein is purified on the basis of a unique biochemical property. In affinity chromatography, the ligand is covalently attached to a matri...

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Lectins from edible mushrooms.

Mushrooms are famous for their nutritional and medicinal values and also for the diversity of bioactive compounds they contain including lectins. The present review is an attempt to summarize and discuss data available on molecular weights, structures, biological properties, N-terminal sequences and possible applications of lectins from edible mushrooms. It further aims to update and discuss/ex...

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Biomedical aspects of lectins.

Studies on lectins are having an increasing impact on medicine, by providing new tools for diagnosis, helping to solve clinical problems, and giving new insights into pathological processes (Lis & Sharon, 1986a, b; Sharon & Lis, 1988). Two early discoveries: that certain lectins are bloodgroup specific while others are mitogenic, have led to their widespread use for blood typing, for assessing ...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1991

ISSN: 0014-5793

DOI: 10.1016/0014-5793(91)80413-w